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Transgenic Core Opens in Bio Engineering Facility

Cell injection procedure in dish

The Transgenic Genome Editing Facility was established in January of 2016 by the Office of the Vice President for Research Graduate Studies with the goal to provide faculty on campus with comprehensive expertise, resources and support in genetic engineering, molecular cloning and delivery of gene editing reagents to experimental systems.  The mission of MSU-TGEF is to support the in-house generation of transgenic organisms, embryos and cells lines in a variety of species using the latest genome editing technologies such as CRISPR/Cas. MSU-TGEF provides support at all stages of genome editing projects, including project consultation, experimental design, construct generation, validation and molecular screening; delivery of of genome editing system components to cells and embryos through transfection, electroporation or microinjection.

The MSU-TGEF program is directed by Drs. Elena Demireva and Huirong Xie. Their leadership brings over 17 years of collective expertise and experience in molecular genetics and reproductive biology to MSU.

To serve the research community MSU-TGEF is currently offering the following categories of services:

  1. Consultation, training and information services
  2. Gene editing and molecular biology
  3. Tissue culture and ES cell line services
  4. Embryo microinjection and manipulation
  5. Cryopreservation and cryorecovery
  6. Rodent-specific services: rederivation, IVF, speed line expansion

Learn more and contact the staff at TGEF by visiting tgef.vprgs.msu.edu